Drug interactions
Indapamide + Nateglinide
Severity: Minor
Indapamide and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-type diuretics can raise blood glucose and may reduce the effectiveness of nateglinide. The effect is usually small at standard indapamide doses.
What this interaction means in plain words
Indapamide and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indapamide belongs to Cardiovascular; Nateglinide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: thiazide-type diuretics can impair insulin secretion and sensitivity.
What to do
Monitor blood glucose when indapamide is started or its dose changed, and adjust antidiabetic therapy if control deteriorates.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indapamide
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Indapamide with Nateglinide?
MediHelp rates the interaction as minor. Indapamide and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide-type diuretics can raise blood glucose and may reduce the effectiveness of nateglinide. The effect is usually small at standard indapamide doses.
How serious is the interaction between Indapamide and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when indapamide is started or its dose changed, and adjust antidiabetic therapy if control deteriorates.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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