Drug interactions
Indapamide + Ofloxacin
Severity: Moderate
Indapamide and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide can cause hypokalemia and hypomagnesemia and has been linked to QT prolongation, which may magnify the QT effect of ofloxacin. This raises the risk of torsades de pointes.
What this interaction means in plain words
Indapamide and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Ofloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation, worsened by diuretic-induced hypokalemia and hypomagnesemia.
What to do
Check potassium and magnesium and correct deficits before and during ofloxacin therapy. Obtain an ECG if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Ofloxacin?
MediHelp rates the interaction as moderate. Indapamide and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide can cause hypokalemia and hypomagnesemia and has been linked to QT prolongation, which may magnify the QT effect of ofloxacin. This raises the risk of torsades de pointes.
How serious is the interaction between Indapamide and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and correct deficits before and during ofloxacin therapy. Obtain an ECG if other QT risk factors are present.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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