Drug interactions
Indapamide + Pazopanib
Severity: Moderate
Indapamide and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are associated with QT prolongation, and indapamide-induced hypokalemia or hypomagnesemia can further raise arrhythmia risk. Torsades de pointes is uncommon but serious.
What this interaction means in plain words
Indapamide and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Pazopanib belongs to Oncology.
Why it happens
Additive QT interval prolongation with electrolyte depletion from the diuretic.
What to do
Obtain baseline ECG and electrolytes, keep potassium and magnesium in the normal range, and repeat ECG periodically during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Indapamide with Pazopanib?
MediHelp rates the interaction as moderate. Indapamide and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are associated with QT prolongation, and indapamide-induced hypokalemia or hypomagnesemia can further raise arrhythmia risk. Torsades de pointes is uncommon but serious.
How serious is the interaction between Indapamide and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline ECG and electrolytes, keep potassium and magnesium in the normal range, and repeat ECG periodically during therapy.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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