Drug interactions
Indapamide + Prednisolone
Severity: Moderate
Indapamide and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide and prednisolone both promote potassium loss, raising the chance of hypokalemia when used together. Low potassium can predispose to arrhythmias, particularly with QT-prolonging drugs.
What this interaction means in plain words
Indapamide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Prednisolone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from thiazide-like diuretic and glucocorticoid mineralocorticoid effects.
What to do
Monitor serum potassium and magnesium and correct deficits promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Prednisolone?
MediHelp rates the interaction as moderate. Indapamide and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide and prednisolone both promote potassium loss, raising the chance of hypokalemia when used together. Low potassium can predispose to arrhythmias, particularly with QT-prolonging drugs.
How serious is the interaction between Indapamide and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and correct deficits promptly.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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