Drug interactions
Indapamide + Quinine
Severity: Major
Indapamide and Quinine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide can prolong the QT interval and cause hypokalemia and hypomagnesemia, which further raise the arrhythmia risk with quinine. The combination is therefore more hazardous than QT effects alone.
What this interaction means in plain words
Indapamide and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indapamide belongs to Cardiovascular; Quinine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, with diuretic-induced electrolyte depletion increasing proarrhythmic susceptibility.
What to do
Check potassium and magnesium before and during treatment and correct deficits; monitor the ECG, or consider an alternative to indapamide.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Quinine?
MediHelp rates the interaction as major. Indapamide and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indapamide can prolong the QT interval and cause hypokalemia and hypomagnesemia, which further raise the arrhythmia risk with quinine. The combination is therefore more hazardous than QT effects alone.
How serious is the interaction between Indapamide and Quinine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium before and during treatment and correct deficits; monitor the ECG, or consider an alternative to indapamide.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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