Drug interactions
Indapamide + Sacubitril-valsartan
Severity: Moderate
Indapamide and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide can cause hypokalemia, hyponatremia and volume depletion, whereas sacubitril-valsartan tends to raise potassium and lower blood pressure. The net potassium effect is unpredictable, and additive hypotension or renal changes may occur.
What this interaction means in plain words
Indapamide and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Opposing effects on potassium handling and additive hypotensive and volume-depleting actions.
What to do
Monitor serum potassium, sodium, creatinine and blood pressure after starting or adjusting therapy. Adjust the diuretic dose if hypotension or volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Indapamide and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide can cause hypokalemia, hyponatremia and volume depletion, whereas sacubitril-valsartan tends to raise potassium and lower blood pressure. The net potassium effect is unpredictable, and additive hypotension or renal changes may occur.
How serious is the interaction between Indapamide and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, sodium, creatinine and blood pressure after starting or adjusting therapy. Adjust the diuretic dose if hypotension or volume depletion develops.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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