Drug interactions
Indapamide + Selpercatinib
Severity: Moderate
Indapamide and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can prolong the QT interval, and indapamide can cause hypokalemia and hypomagnesemia that further increase arrhythmia risk. The combination may predispose to torsades de pointes.
What this interaction means in plain words
Indapamide and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Selpercatinib belongs to Oncology.
Why it happens
Additive QT prolongation with diuretic-induced electrolyte depletion.
What to do
Monitor ECG and correct potassium, magnesium and calcium before and during selpercatinib treatment. Consider an alternative antihypertensive or diuretic if QTc rises substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Selpercatinib
Frequently asked questions
Can I take Indapamide with Selpercatinib?
MediHelp rates the interaction as moderate. Indapamide and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selpercatinib can prolong the QT interval, and indapamide can cause hypokalemia and hypomagnesemia that further increase arrhythmia risk. The combination may predispose to torsades de pointes.
How serious is the interaction between Indapamide and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium, magnesium and calcium before and during selpercatinib treatment. Consider an alternative antihypertensive or diuretic if QTc rises substantially.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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