Drug interactions
Indapamide + Spironolactone
Severity: Moderate
Indapamide and Spironolactone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide lowers potassium while spironolactone raises it, so they may offset each other. Hyperkalemia can still develop, particularly with renal impairment, diabetes, or concurrent ACE inhibitors or ARBs.
What this interaction means in plain words
Indapamide and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Spironolactone belongs to Cardiovascular.
Why it happens
Opposing renal effects: thiazide-like kaliuresis versus aldosterone receptor antagonism reducing potassium excretion.
What to do
Monitor serum potassium and creatinine at baseline, early after initiation and periodically afterwards. Avoid potassium supplements unless hypokalemia is confirmed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Indapamide with Spironolactone?
MediHelp rates the interaction as moderate. Indapamide and Spironolactone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide lowers potassium while spironolactone raises it, so they may offset each other. Hyperkalemia can still develop, particularly with renal impairment, diabetes, or concurrent ACE inhibitors or ARBs.
How serious is the interaction between Indapamide and Spironolactone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and creatinine at baseline, early after initiation and periodically afterwards. Avoid potassium supplements unless hypokalemia is confirmed.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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