Drug interactions
Indapamide + Tadalafil
Severity: Minor
Indapamide and Tadalafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil may add to the blood pressure lowering of indapamide, particularly with volume depletion. Symptomatic hypotension is uncommon.
What this interaction means in plain words
Indapamide and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indapamide belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive blood pressure lowering from vasodilation and diuresis.
What to do
Monitor blood pressure when starting tadalafil and counsel about orthostatic symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Tadalafil?
MediHelp rates the interaction as minor. Indapamide and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tadalafil may add to the blood pressure lowering of indapamide, particularly with volume depletion. Symptomatic hypotension is uncommon.
How serious is the interaction between Indapamide and Tadalafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting tadalafil and counsel about orthostatic symptoms.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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