Drug interactions
Indapamide + Tolmetin
Severity: Moderate
Indapamide and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolmetin may reduce the antihypertensive and diuretic effect of indapamide. The combination may also raise the risk of renal impairment in volume-depleted or elderly patients.
What this interaction means in plain words
Indapamide and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Tolmetin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins leads to sodium and water retention and lowered renal perfusion, opposing the diuretic.
What to do
Monitor blood pressure, edema and renal function and electrolytes. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Tolmetin?
MediHelp rates the interaction as moderate. Indapamide and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolmetin may reduce the antihypertensive and diuretic effect of indapamide. The combination may also raise the risk of renal impairment in volume-depleted or elderly patients.
How serious is the interaction between Indapamide and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema and renal function and electrolytes. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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