Drug interactions
Indapamide + Triamterene
Severity: Moderate
Indapamide and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene retains potassium while indapamide depletes it, so the pair can balance potassium but may also cause hyperkalemia in susceptible patients. Risk is higher with renal impairment, older age and other potassium-raising agents.
What this interaction means in plain words
Indapamide and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Opposing renal potassium handling: ENaC blockade by triamterene versus thiazide-like kaliuresis.
What to do
Monitor serum potassium and renal function regularly, and avoid potassium supplements and salt substitutes unless hypokalemia is documented.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Indapamide with Triamterene?
MediHelp rates the interaction as moderate. Indapamide and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triamterene retains potassium while indapamide depletes it, so the pair can balance potassium but may also cause hyperkalemia in susceptible patients. Risk is higher with renal impairment, older age and other potassium-raising agents.
How serious is the interaction between Indapamide and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function regularly, and avoid potassium supplements and salt substitutes unless hypokalemia is documented.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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