Drug interactions
Indapamide + Valsartan
Severity: Minor
Indapamide and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide tends to lower potassium while valsartan tends to raise it, so the net effect varies. The combination is commonly used, but volume depletion and hypotension can occur, particularly at initiation.
What this interaction means in plain words
Indapamide and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indapamide belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Opposing potassium effects (kaliuresis versus aldosterone antagonism) and additive blood pressure lowering.
What to do
Check potassium, creatinine and blood pressure after initiation or dose changes. Reduce the diuretic dose if volume depletion develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indapamide and Valsartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Indapamide
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Indapamide with Valsartan?
MediHelp rates the interaction as minor. Indapamide and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indapamide tends to lower potassium while valsartan tends to raise it, so the net effect varies. The combination is commonly used, but volume depletion and hypotension can occur, particularly at initiation.
How serious is the interaction between Indapamide and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium, creatinine and blood pressure after initiation or dose changes. Reduce the diuretic dose if volume depletion develops.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
