Drug interactions
Indinavir + Insulin degludec-liraglutide
Severity: Moderate
Indinavir and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir, an HIV protease inhibitor, is associated with insulin resistance, hyperglycemia and new-onset or worsening diabetes. This may reduce the effectiveness of insulin degludec/liraglutide.
What this interaction means in plain words
Indinavir and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Protease inhibitors impair insulin-mediated glucose uptake, causing insulin resistance.
What to do
Monitor glucose frequently when starting indinavir and increase antidiabetic doses as required. Reassess doses if the protease inhibitor is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Frequently asked questions
Can I take Indinavir with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Indinavir and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir, an HIV protease inhibitor, is associated with insulin resistance, hyperglycemia and new-onset or worsening diabetes. This may reduce the effectiveness of insulin degludec/liraglutide.
How serious is the interaction between Indinavir and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose frequently when starting indinavir and increase antidiabetic doses as required. Reassess doses if the protease inhibitor is stopped.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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