Drug interactions
Indinavir + Insulin glulisine
Severity: Moderate
Indinavir and Insulin glulisine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is well known to cause insulin resistance and hyperglycemia, which may weaken the effect of insulin glulisine. Insulin requirements may increase and diabetes may worsen.
What this interaction means in plain words
Indinavir and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits GLUT4-mediated glucose uptake and impairs insulin sensitivity.
What to do
Monitor blood glucose after starting indinavir and increase the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Frequently asked questions
Can I take Indinavir with Insulin glulisine?
MediHelp rates the interaction as moderate. Indinavir and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir is well known to cause insulin resistance and hyperglycemia, which may weaken the effect of insulin glulisine. Insulin requirements may increase and diabetes may worsen.
How serious is the interaction between Indinavir and Insulin glulisine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting indinavir and increase the insulin dose as needed.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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