Drug interactions
Indinavir + Metformin-repaglinide
Severity: Moderate
Indinavir and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir is a strong CYP3A4 inhibitor and can raise repaglinide concentrations, increasing the risk of hypoglycemia. Repaglinide is also metabolized by CYP2C8, which limits but does not remove the effect. Protease inhibitors may additionally alter glucose metabolism.
What this interaction means in plain words
Indinavir and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 reduces first-pass and systemic metabolism of repaglinide.
What to do
Monitor blood glucose closely and consider reducing the repaglinide dose when indinavir is started. Counsel patients on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Frequently asked questions
Can I take Indinavir with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Indinavir and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir is a strong CYP3A4 inhibitor and can raise repaglinide concentrations, increasing the risk of hypoglycemia. Repaglinide is also metabolized by CYP2C8, which limits but does not remove the effect. Protease inhibitors may additionally alter glucose metabolism.
How serious is the interaction between Indinavir and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and consider reducing the repaglinide dose when indinavir is started. Counsel patients on hypoglycemia symptoms.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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