Drug interactions
Indinavir + Nateglinide
Severity: Moderate
Indinavir and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir can induce insulin resistance and hyperglycemia, which may diminish the glucose-lowering effect of nateglinide. Glycemic control may worsen during therapy.
What this interaction means in plain words
Indinavir and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism through protease inhibitor-associated insulin resistance.
What to do
Monitor blood glucose more often when indinavir is started or stopped. Adjust the nateglinide dose or add other therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Indinavir with Nateglinide?
MediHelp rates the interaction as moderate. Indinavir and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir can induce insulin resistance and hyperglycemia, which may diminish the glucose-lowering effect of nateglinide. Glycemic control may worsen during therapy.
How serious is the interaction between Indinavir and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often when indinavir is started or stopped. Adjust the nateglinide dose or add other therapy if control worsens.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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