Drug interactions
Indinavir + Oxybutynin
Severity: Moderate
Indinavir and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may raise oxybutynin concentrations, increasing anticholinergic effects such as dry mouth, constipation and confusion.
What this interaction means in plain words
Indinavir and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits CYP3A4 metabolism of oxybutynin.
What to do
Monitor for anticholinergic adverse effects and reduce the oxybutynin dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Frequently asked questions
Can I take Indinavir with Oxybutynin?
MediHelp rates the interaction as moderate. Indinavir and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and may raise oxybutynin concentrations, increasing anticholinergic effects such as dry mouth, constipation and confusion.
How serious is the interaction between Indinavir and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and reduce the oxybutynin dose if they occur.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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