Drug interactions
Indinavir + Pantoprazole
Severity: Moderate
Indinavir and Pantoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir absorption is better in an acidic stomach, and pantoprazole may reduce its concentrations. This could weaken antiviral efficacy.
What this interaction means in plain words
Indinavir and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Raised gastric pH reduces the solubility and absorption of indinavir.
What to do
Monitor virologic response and consider an alternative acid-suppression strategy or antiretroviral agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Indinavir with Pantoprazole?
MediHelp rates the interaction as moderate. Indinavir and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir absorption is better in an acidic stomach, and pantoprazole may reduce its concentrations. This could weaken antiviral efficacy.
How serious is the interaction between Indinavir and Pantoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor virologic response and consider an alternative acid-suppression strategy or antiretroviral agent.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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