Drug interactions
Indinavir + Pazopanib
Severity: Major
Indinavir and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir strongly inhibits CYP3A4 and can markedly increase pazopanib exposure, raising the risk of hepatotoxicity, hypertension and QT prolongation.
What this interaction means in plain words
Indinavir and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Strong inhibition of CYP3A4 metabolism of pazopanib.
What to do
Choose an alternative antiretroviral without strong CYP3A4 inhibition. If unavoidable, reduce pazopanib to 400 mg daily and monitor liver function and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Indinavir with Pazopanib?
MediHelp rates the interaction as major. Indinavir and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indinavir strongly inhibits CYP3A4 and can markedly increase pazopanib exposure, raising the risk of hepatotoxicity, hypertension and QT prolongation.
How serious is the interaction between Indinavir and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose an alternative antiretroviral without strong CYP3A4 inhibition. If unavoidable, reduce pazopanib to 400 mg daily and monitor liver function and ECG.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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