Drug interactions
Indinavir + Pioglitazone
Severity: Minor
Indinavir and Pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may modestly increase pioglitazone exposure. Because CYP2C8 is the main route of pioglitazone clearance, the effect is expected to be small.
What this interaction means in plain words
Indinavir and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4-mediated pioglitazone metabolism.
What to do
No empiric dose change is needed; monitor for edema, weight gain and glucose changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pioglitazone
Frequently asked questions
Can I take Indinavir with Pioglitazone?
MediHelp rates the interaction as minor. Indinavir and Pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indinavir inhibits CYP3A4 and may modestly increase pioglitazone exposure. Because CYP2C8 is the main route of pioglitazone clearance, the effect is expected to be small.
How serious is the interaction between Indinavir and Pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed; monitor for edema, weight gain and glucose changes.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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