Drug interactions
Indinavir + Prednisolone
Severity: Moderate
Indinavir and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and can raise corticosteroid exposure. Prolonged use may increase steroid adverse effects such as Cushingoid features and adrenal suppression, though prednisolone is affected less than some other steroids.
What this interaction means in plain words
Indinavir and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Indinavir inhibits CYP3A4 and P-glycoprotein, reducing prednisolone clearance.
What to do
Monitor for corticosteroid excess during long-term use and use the lowest effective prednisolone dose. Consider an alternative steroid plan if prolonged therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Indinavir with Prednisolone?
MediHelp rates the interaction as moderate. Indinavir and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and can raise corticosteroid exposure. Prolonged use may increase steroid adverse effects such as Cushingoid features and adrenal suppression, though prednisolone is affected less than some other steroids.
How serious is the interaction between Indinavir and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid excess during long-term use and use the lowest effective prednisolone dose. Consider an alternative steroid plan if prolonged therapy is needed.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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