Drug interactions
Indinavir + Sacubitril-valsartan
Severity: Minor
Indinavir and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is taken up into the liver by OATP1B1, which protease inhibitors may inhibit. This could raise valsartan exposure and increase hypotension or renal effects. The clinical effect is likely modest.
What this interaction means in plain words
Indinavir and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of valsartan.
What to do
No empirical dose change; monitor blood pressure, potassium and renal function when starting or stopping indinavir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Indinavir with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Indinavir and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is taken up into the liver by OATP1B1, which protease inhibitors may inhibit. This could raise valsartan exposure and increase hypotension or renal effects. The clinical effect is likely modest.
How serious is the interaction between Indinavir and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change; monitor blood pressure, potassium and renal function when starting or stopping indinavir.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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