Drug interactions
Indinavir + Tolterodine
Severity: Moderate
Indinavir and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and can raise tolterodine levels, especially in patients lacking CYP2D6 activity. This increases anticholinergic adverse effects and possible QT effects.
What this interaction means in plain words
Indinavir and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by indinavir reduces tolterodine metabolism.
What to do
Limit tolterodine to 1 mg twice daily with strong CYP3A4 inhibitors and monitor for anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolterodine
Frequently asked questions
Can I take Indinavir with Tolterodine?
MediHelp rates the interaction as moderate. Indinavir and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and can raise tolterodine levels, especially in patients lacking CYP2D6 activity. This increases anticholinergic adverse effects and possible QT effects.
How serious is the interaction between Indinavir and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit tolterodine to 1 mg twice daily with strong CYP3A4 inhibitors and monitor for anticholinergic effects.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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