Drug interactions
Indinavir + Triamcinolone
Severity: Major
Indinavir and Triamcinolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir can substantially raise triamcinolone exposure, leading to Cushing syndrome and adrenal suppression, including after intra-articular or epidural injection. Cases have occurred with ritonavir-boosted regimens, and the effect can persist for weeks after an injection.
What this interaction means in plain words
Indinavir and Triamcinolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4 by indinavir decreases triamcinolone clearance.
What to do
Avoid long-term or repeated triamcinolone with indinavir if possible, and consider alternatives such as beclomethasone or prednisolone. If used, monitor for Cushingoid features and adrenal suppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Triamcinolone
- Smallpox vaccine live + Triamcinolone Contraindicated
- Triamcinolone + Zoster vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Triamcinolone Major
- Aldesleukin + Triamcinolone Major
- Atazanavir + Triamcinolone Major
- Axicabtagene ciloleucel + Triamcinolone Major
Frequently asked questions
Can I take Indinavir with Triamcinolone?
MediHelp rates the interaction as major. Indinavir and Triamcinolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indinavir can substantially raise triamcinolone exposure, leading to Cushing syndrome and adrenal suppression, including after intra-articular or epidural injection. Cases have occurred with ritonavir-boosted regimens, and the effect can persist for weeks after an injection.
How serious is the interaction between Indinavir and Triamcinolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term or repeated triamcinolone with indinavir if possible, and consider alternatives such as beclomethasone or prednisolone. If used, monitor for Cushingoid features and adrenal suppression.
What other medicines interact with Triamcinolone?
MediHelp also lists interactions of Triamcinolone with, for example, Smallpox vaccine live, Zoster vaccine live, Adenovirus types 4 and 7 live. The full list is on the Triamcinolone page.
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