Drug interactions
Indinavir + Valsartan
Severity: Minor
Indinavir and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is taken up into the liver by OATP1B1, which indinavir may inhibit. Valsartan exposure could therefore increase, with a risk of more pronounced blood pressure lowering. The effect is predicted rather than well demonstrated.
What this interaction means in plain words
Indinavir and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Predicted inhibition of OATP1B1-mediated hepatic uptake of valsartan.
What to do
No empirical dose change is needed; monitor blood pressure and for hypotension after starting indinavir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Indinavir with Valsartan?
MediHelp rates the interaction as minor. Indinavir and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is taken up into the liver by OATP1B1, which indinavir may inhibit. Valsartan exposure could therefore increase, with a risk of more pronounced blood pressure lowering. The effect is predicted rather than well demonstrated.
How serious is the interaction between Indinavir and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor blood pressure and for hypotension after starting indinavir.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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