Drug interactions
Indinavir + Vincristine
Severity: Major
Indinavir and Vincristine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may raise vincristine exposure, increasing the risk of neurotoxicity and constipation or ileus.
What this interaction means in plain words
Indinavir and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Indinavir inhibits CYP3A4, reducing vincristine clearance.
What to do
Use an antiretroviral regimen without CYP3A inhibition if possible. If coadministered, monitor for neuropathy and constipation and reduce the vincristine dose as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Indinavir with Vincristine?
MediHelp rates the interaction as major. Indinavir and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indinavir inhibits CYP3A4 and may raise vincristine exposure, increasing the risk of neurotoxicity and constipation or ileus.
How serious is the interaction between Indinavir and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an antiretroviral regimen without CYP3A inhibition if possible. If coadministered, monitor for neuropathy and constipation and reduce the vincristine dose as needed.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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