Drug interactions
Influenza a vaccine + Vinorelbine
Severity: Moderate
Influenza a vaccine and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Myelosuppressive chemotherapy can blunt the antibody response to influenza vaccination, including H5N1 vaccines. Protection may be lower than expected.
What this interaction means in plain words
Influenza a vaccine and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression reduces vaccine immune response.
What to do
If possible, vaccinate before starting chemotherapy or at a time of recovered counts between cycles. Do not rely on the vaccine alone for protection and consider the response may be reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Frequently asked questions
Can I take Influenza a vaccine with Vinorelbine?
MediHelp rates the interaction as moderate. Influenza a vaccine and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Myelosuppressive chemotherapy can blunt the antibody response to influenza vaccination, including H5N1 vaccines. Protection may be lower than expected.
How serious is the interaction between Influenza a vaccine and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If possible, vaccinate before starting chemotherapy or at a time of recovered counts between cycles. Do not rely on the vaccine alone for protection and consider the response may be reduced.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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