Drug interactions
Influenza virus vaccine adjuvanted + Vincristine
Severity: Moderate
Influenza virus vaccine adjuvanted and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vincristine-based chemotherapy suppresses immune function and can blunt the antibody response to the adjuvanted H5N1 vaccine. Patients may therefore be inadequately protected.
What this interaction means in plain words
Influenza virus vaccine adjuvanted and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression reduces vaccine immune response.
What to do
Where possible, vaccinate before starting chemotherapy or during periods of recovery. Do not rely on the vaccine alone for protection in immunosuppressed patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Influenza virus vaccine adjuvanted with Vincristine?
MediHelp rates the interaction as moderate. Influenza virus vaccine adjuvanted and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vincristine-based chemotherapy suppresses immune function and can blunt the antibody response to the adjuvanted H5N1 vaccine. Patients may therefore be inadequately protected.
How serious is the interaction between Influenza virus vaccine adjuvanted and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, vaccinate before starting chemotherapy or during periods of recovery. Do not rely on the vaccine alone for protection in immunosuppressed patients.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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