Drug interactions
Influenza virus vaccine adjuvanted + Vinorelbine
Severity: Moderate
Influenza virus vaccine adjuvanted and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Myelosuppressive chemotherapy can blunt the antibody response to adjuvanted H5N1 influenza vaccine. Protection may be lower than expected.
What this interaction means in plain words
Influenza virus vaccine adjuvanted and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression reduces vaccine immune response.
What to do
If possible, vaccinate before starting chemotherapy or when counts have recovered between cycles. Do not rely on the vaccine alone for protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Frequently asked questions
Can I take Influenza virus vaccine adjuvanted with Vinorelbine?
MediHelp rates the interaction as moderate. Influenza virus vaccine adjuvanted and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Myelosuppressive chemotherapy can blunt the antibody response to adjuvanted H5N1 influenza vaccine. Protection may be lower than expected.
How serious is the interaction between Influenza virus vaccine adjuvanted and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If possible, vaccinate before starting chemotherapy or when counts have recovered between cycles. Do not rely on the vaccine alone for protection.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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