Drug interactions
Influenza virus vaccine quadrivalent adjuvanted + Irinotecan
Severity: Moderate
Influenza virus vaccine quadrivalent adjuvanted and Irinotecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Myelosuppressive chemotherapy may blunt antibody response to influenza vaccination. The inactivated adjuvanted vaccine is not harmful, but protection may be reduced.
What this interaction means in plain words
Influenza virus vaccine quadrivalent adjuvanted and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression and lymphopenia reduce vaccine immunogenicity.
What to do
Vaccinate ideally before chemotherapy starts or between cycles when counts recover. Do not withhold annual influenza vaccination in patients on treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent adjuvanted with Irinotecan?
MediHelp rates the interaction as moderate. Influenza virus vaccine quadrivalent adjuvanted and Irinotecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Myelosuppressive chemotherapy may blunt antibody response to influenza vaccination. The inactivated adjuvanted vaccine is not harmful, but protection may be reduced.
How serious is the interaction between Influenza virus vaccine quadrivalent adjuvanted and Irinotecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate ideally before chemotherapy starts or between cycles when counts recover. Do not withhold annual influenza vaccination in patients on treatment.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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