Drug interactions
Influenza virus vaccine quadrivalent adjuvanted + Vincristine
Severity: Moderate
Influenza virus vaccine quadrivalent adjuvanted and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy can blunt the antibody response to inactivated influenza vaccine, so protection may be lower than expected. The vaccine is inactivated and safe to give, and vaccination is generally still advised in patients receiving chemotherapy.
What this interaction means in plain words
Influenza virus vaccine quadrivalent adjuvanted and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced myelosuppression and lymphocyte depletion reduce the humoral response to vaccination.
What to do
Vaccinate before chemotherapy starts or between cycles when counts have recovered, where possible. Do not withhold vaccination in patients who need it.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent adjuvanted with Vincristine?
MediHelp rates the interaction as moderate. Influenza virus vaccine quadrivalent adjuvanted and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chemotherapy can blunt the antibody response to inactivated influenza vaccine, so protection may be lower than expected. The vaccine is inactivated and safe to give, and vaccination is generally still advised in patients receiving chemotherapy.
How serious is the interaction between Influenza virus vaccine quadrivalent adjuvanted and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before chemotherapy starts or between cycles when counts have recovered, where possible. Do not withhold vaccination in patients who need it.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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