Drug interactions
Influenza virus vaccine quadrivalent adjuvanted + Vinorelbine
Severity: Moderate
Influenza virus vaccine quadrivalent adjuvanted and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Myelosuppressive chemotherapy can blunt antibody responses to inactivated influenza vaccine. The vaccine is not harmful in itself, but protection may be reduced in patients on vinorelbine.
What this interaction means in plain words
Influenza virus vaccine quadrivalent adjuvanted and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced suppression of lymphocytes and immune function reduces vaccine immunogenicity.
What to do
Still vaccinate, since influenza risk is high in cancer patients; ideally give the vaccine before chemotherapy cycles or at the point of expected counts recovery. Do not rely on a single dose for full protection and reinforce other preventive measures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent adjuvanted with Vinorelbine?
MediHelp rates the interaction as moderate. Influenza virus vaccine quadrivalent adjuvanted and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Myelosuppressive chemotherapy can blunt antibody responses to inactivated influenza vaccine. The vaccine is not harmful in itself, but protection may be reduced in patients on vinorelbine.
How serious is the interaction between Influenza virus vaccine quadrivalent adjuvanted and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Still vaccinate, since influenza risk is high in cancer patients; ideally give the vaccine before chemotherapy cycles or at the point of expected counts recovery. Do not rely on a single dose for full protection and reinforce other preventive measures.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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