Drug interactions
Influenza virus vaccine quadrivalent recombinant + Prednisolone
Severity: Minor
Influenza virus vaccine quadrivalent recombinant and Prednisolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids at immunosuppressive doses may reduce the antibody response to inactivated or recombinant influenza vaccines. The vaccine is still recommended because it is non-live and safe.
What this interaction means in plain words
Influenza virus vaccine quadrivalent recombinant and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Corticosteroid immunosuppression diminishes the humoral response to vaccine antigens.
What to do
Give the vaccine as recommended, preferably before or during low-dose steroid therapy. Do not delay vaccination, but consider that protection may be reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent recombinant with Prednisolone?
MediHelp rates the interaction as minor. Influenza virus vaccine quadrivalent recombinant and Prednisolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic corticosteroids at immunosuppressive doses may reduce the antibody response to inactivated or recombinant influenza vaccines. The vaccine is still recommended because it is non-live and safe.
How serious is the interaction between Influenza virus vaccine quadrivalent recombinant and Prednisolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine as recommended, preferably before or during low-dose steroid therapy. Do not delay vaccination, but consider that protection may be reduced.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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