Drug interactions
Influenza virus vaccine trivalent adjuvanted + Rituximab
Severity: Moderate
Influenza virus vaccine trivalent adjuvanted and Rituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
B-cell depletion by rituximab reduces the immune response to adjuvanted trivalent influenza vaccine. Vaccinated patients may remain at risk of influenza.
What this interaction means in plain words
Influenza virus vaccine trivalent adjuvanted and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rituximab-mediated CD20-positive B-cell depletion impairs humoral vaccine responses.
What to do
Vaccinate at least 4 weeks before a rituximab course where feasible. If given during therapy, treat the response as uncertain and maintain other protective measures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Influenza virus vaccine trivalent adjuvanted and Rituximab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Rituximab
Frequently asked questions
Can I take Influenza virus vaccine trivalent adjuvanted with Rituximab?
MediHelp rates the interaction as moderate. Influenza virus vaccine trivalent adjuvanted and Rituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. B-cell depletion by rituximab reduces the immune response to adjuvanted trivalent influenza vaccine. Vaccinated patients may remain at risk of influenza.
How serious is the interaction between Influenza virus vaccine trivalent adjuvanted and Rituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 4 weeks before a rituximab course where feasible. If given during therapy, treat the response as uncertain and maintain other protective measures.
What other medicines interact with Rituximab?
MediHelp also lists interactions of Rituximab with, for example, Adenovirus types 4 and 7 live, Baricitinib, Certolizumab pegol. The full list is on the Rituximab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
