Drug interactions
Inotuzumab + Isoflurane
Severity: Moderate
Inotuzumab and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inotuzumab ozogamicin can prolong the QT interval, and isoflurane may add to this effect. The combination may raise the risk of torsades de pointes.
What this interaction means in plain words
Inotuzumab and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization.
What to do
Check ECG and electrolytes before anesthesia and correct potassium and magnesium. Monitor the QTc perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Frequently asked questions
Can I take Inotuzumab with Isoflurane?
MediHelp rates the interaction as moderate. Inotuzumab and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inotuzumab ozogamicin can prolong the QT interval, and isoflurane may add to this effect. The combination may raise the risk of torsades de pointes.
How serious is the interaction between Inotuzumab and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before anesthesia and correct potassium and magnesium. Monitor the QTc perioperatively.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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