Drug interactions
Inotuzumab + Methadone
Severity: Major
Inotuzumab and Methadone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inotuzumab ozogamicin can prolong the QT interval, and methadone has the same effect, so the combination increases the risk of torsades de pointes. The risk is higher with electrolyte disturbances.
What this interaction means in plain words
Inotuzumab and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Obtain an ECG and electrolytes before starting and periodically afterwards, correcting potassium and magnesium. Consider an alternative opioid if the QTc becomes prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Frequently asked questions
Can I take Inotuzumab with Methadone?
MediHelp rates the interaction as major. Inotuzumab and Methadone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Inotuzumab ozogamicin can prolong the QT interval, and methadone has the same effect, so the combination increases the risk of torsades de pointes. The risk is higher with electrolyte disturbances.
How serious is the interaction between Inotuzumab and Methadone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and electrolytes before starting and periodically afterwards, correcting potassium and magnesium. Consider an alternative opioid if the QTc becomes prolonged.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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