Drug interactions
Inotuzumab + Trastuzumab
Severity: Moderate
Inotuzumab and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inotuzumab ozogamicin commonly causes neutropenia and thrombocytopenia, and trastuzumab with myelosuppressive therapy has been associated with more neutropenia. Infection risk may be increased.
What this interaction means in plain words
Inotuzumab and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive myelosuppression, mainly from the calicheamicin payload of inotuzumab.
What to do
Monitor blood counts and for infection during treatment. Interrupt or reduce inotuzumab per labeling for severe neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trastuzumab
Frequently asked questions
Can I take Inotuzumab with Trastuzumab?
MediHelp rates the interaction as moderate. Inotuzumab and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inotuzumab ozogamicin commonly causes neutropenia and thrombocytopenia, and trastuzumab with myelosuppressive therapy has been associated with more neutropenia. Infection risk may be increased.
How serious is the interaction between Inotuzumab and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for infection during treatment. Interrupt or reduce inotuzumab per labeling for severe neutropenia.
What other medicines interact with Trastuzumab?
MediHelp also lists interactions of Trastuzumab with, for example, Daunorubicin, Doxorubicin liposomal, Doxorubicin. The full list is on the Trastuzumab page.
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