Drug interactions
Insulin aspart + Insulin degludec-liraglutide
Severity: Moderate
Insulin aspart and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding prandial insulin to a basal insulin and GLP-1 agonist combination increases the glucose-lowering effect and the risk of hypoglycemia. This is a recognized regimen but needs dose titration.
What this interaction means in plain words
Insulin aspart and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart belongs to Endocrine; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose-lowering effect of insulin and GLP-1 receptor agonism.
What to do
Titrate doses on the basis of glucose monitoring and reduce the insulin aspart dose if hypoglycemia occurs. Review total insulin dose when starting or stopping the combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Insulin aspart
Frequently asked questions
Can I take Insulin aspart with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Insulin aspart and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding prandial insulin to a basal insulin and GLP-1 agonist combination increases the glucose-lowering effect and the risk of hypoglycemia. This is a recognized regimen but needs dose titration.
How serious is the interaction between Insulin aspart and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate doses on the basis of glucose monitoring and reduce the insulin aspart dose if hypoglycemia occurs. Review total insulin dose when starting or stopping the combination.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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