Drug interactions
Insulin aspart + Mecasermin
Severity: Moderate
Insulin aspart and Mecasermin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mecasermin and insulin both lower blood glucose through related receptor pathways. Used together they can cause additive and sometimes severe hypoglycemia.
What this interaction means in plain words
Insulin aspart and Mecasermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart belongs to Endocrine; Mecasermin belongs to Endocrine.
Why it happens
Additive glucose lowering through insulin and IGF-1 receptor activation.
What to do
Monitor blood glucose frequently and reduce the insulin dose if needed. Give mecasermin with a meal or snack.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mecasermin
Other interactions of Insulin aspart
Frequently asked questions
Can I take Insulin aspart with Mecasermin?
MediHelp rates the interaction as moderate. Insulin aspart and Mecasermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mecasermin and insulin both lower blood glucose through related receptor pathways. Used together they can cause additive and sometimes severe hypoglycemia.
How serious is the interaction between Insulin aspart and Mecasermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently and reduce the insulin dose if needed. Give mecasermin with a meal or snack.
What other medicines interact with Mecasermin?
MediHelp also lists interactions of Mecasermin with, for example, Gliclazide, Glyburide-metformin, Insulin degludec-insulin aspart. The full list is on the Mecasermin page.
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