Drug interactions
Insulin degludec-insulin aspart + Mecasermin
Severity: Major
Insulin degludec-insulin aspart and Mecasermin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mecasermin is recombinant IGF-1 and has insulin-like glucose-lowering activity, so combining it with insulin can cause additive and sometimes severe hypoglycemia.
What this interaction means in plain words
Insulin degludec-insulin aspart and Mecasermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec-insulin aspart belongs to Endocrine; Mecasermin belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect: IGF-1 acts on insulin receptors and IGF-1 receptors to lower blood glucose.
What to do
Give mecasermin with or shortly after a meal and monitor blood glucose closely. Reduce the insulin dose as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Insulin degludec-insulin aspart and Mecasermin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Pioglitazone Major
- Insulin degludec-insulin aspart + Pramlintide Major
Other interactions of Mecasermin
Frequently asked questions
Can I take Insulin degludec-insulin aspart with Mecasermin?
MediHelp rates the interaction as major. Insulin degludec-insulin aspart and Mecasermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mecasermin is recombinant IGF-1 and has insulin-like glucose-lowering activity, so combining it with insulin can cause additive and sometimes severe hypoglycemia.
How serious is the interaction between Insulin degludec-insulin aspart and Mecasermin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give mecasermin with or shortly after a meal and monitor blood glucose closely. Reduce the insulin dose as needed.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
