Drug interactions
Insulin aspart + Metformin-repaglinide
Severity: Moderate
Insulin aspart and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining insulin with metformin and repaglinide produces additive glucose lowering and increases the risk of hypoglycemia, especially if doses are not adjusted. This is a recognized and often intended combination.
What this interaction means in plain words
Insulin aspart and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose-lowering effects.
What to do
Monitor blood glucose frequently when starting the combination and reduce the insulin or repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Insulin aspart
Frequently asked questions
Can I take Insulin aspart with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Insulin aspart and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining insulin with metformin and repaglinide produces additive glucose lowering and increases the risk of hypoglycemia, especially if doses are not adjusted. This is a recognized and often intended combination.
How serious is the interaction between Insulin aspart and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when starting the combination and reduce the insulin or repaglinide dose if hypoglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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