Drug interactions
Insulin aspart + Nateglinide
Severity: Moderate
Insulin aspart and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nateglinide stimulates insulin release and adds to the glucose-lowering effect of insulin, raising the risk of hypoglycemia. The risk is greatest with missed or delayed meals.
What this interaction means in plain words
Insulin aspart and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive glucose lowering from exogenous insulin and meglitinide-stimulated pancreatic insulin secretion.
What to do
Monitor blood glucose and reduce the insulin or nateglinide dose if hypoglycemia occurs. Advise taking nateglinide only with meals.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Insulin aspart with Nateglinide?
MediHelp rates the interaction as moderate. Insulin aspart and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nateglinide stimulates insulin release and adds to the glucose-lowering effect of insulin, raising the risk of hypoglycemia. The risk is greatest with missed or delayed meals.
How serious is the interaction between Insulin aspart and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the insulin or nateglinide dose if hypoglycemia occurs. Advise taking nateglinide only with meals.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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