Drug interactions
Insulin aspart + Nelfinavir
Severity: Moderate
Insulin aspart and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir has been associated with insulin resistance and hyperglycemia, which may raise insulin requirements.
What this interaction means in plain words
Insulin aspart and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart belongs to Endocrine; Nelfinavir belongs to Anti Virals.
Why it happens
Protease inhibitors may reduce peripheral insulin sensitivity, antagonizing insulin.
What to do
Monitor glucose more frequently when nelfinavir is started or stopped. Adjust the insulin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Insulin aspart with Nelfinavir?
MediHelp rates the interaction as moderate. Insulin aspart and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir has been associated with insulin resistance and hyperglycemia, which may raise insulin requirements.
How serious is the interaction between Insulin aspart and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose more frequently when nelfinavir is started or stopped. Adjust the insulin dose.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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