Drug interactions
Insulin aspart + Pasireotide
Severity: Moderate
Insulin aspart and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide frequently causes hyperglycemia, and it can also shift glucose control unpredictably in patients on insulin. Insulin requirements may change substantially after starting or stopping pasireotide.
What this interaction means in plain words
Insulin aspart and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart belongs to Endocrine; Pasireotide belongs to Endocrine.
Why it happens
Pasireotide suppresses insulin and incretin (GLP-1, GIP) secretion, opposing the glucose-lowering effect of exogenous insulin.
What to do
Monitor blood glucose closely when pasireotide is started, adjusted or stopped. Titrate insulin aspart dose to glucose results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Insulin aspart with Pasireotide?
MediHelp rates the interaction as moderate. Insulin aspart and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide frequently causes hyperglycemia, and it can also shift glucose control unpredictably in patients on insulin. Insulin requirements may change substantially after starting or stopping pasireotide.
How serious is the interaction between Insulin aspart and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when pasireotide is started, adjusted or stopped. Titrate insulin aspart dose to glucose results.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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