Drug interactions
Anagrelide + Pasireotide
Severity: Major
Anagrelide and Pasireotide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide can prolong the QT interval and slow the heart rate, and anagrelide may add to the QT effect. Combined use increases the risk of ventricular arrhythmia.
What this interaction means in plain words
Anagrelide and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Pasireotide belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation, with bradycardia from pasireotide as an additional risk.
What to do
Avoid if possible. If co-use is needed, check ECG at baseline and during therapy and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Asenapine + Pasireotide Major
Frequently asked questions
Can I take Anagrelide with Pasireotide?
MediHelp rates the interaction as major. Anagrelide and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pasireotide can prolong the QT interval and slow the heart rate, and anagrelide may add to the QT effect. Combined use increases the risk of ventricular arrhythmia.
How serious is the interaction between Anagrelide and Pasireotide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If co-use is needed, check ECG at baseline and during therapy and correct potassium and magnesium.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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