Drug interactions
Insulin aspart + Sacubitril-valsartan
Severity: Moderate
Insulin aspart and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockade may modestly improve insulin sensitivity, and neprilysin inhibition may also influence glucose handling, so insulin requirements can fall. This may increase the risk of hypoglycemia, particularly at the start of therapy.
What this interaction means in plain words
Insulin aspart and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart belongs to Endocrine; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Improved insulin sensitivity from RAAS blockade produces an additive glucose-lowering effect with insulin.
What to do
Monitor blood glucose more closely when starting or changing sacubitril-valsartan. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Insulin aspart
Frequently asked questions
Can I take Insulin aspart with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Insulin aspart and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockade may modestly improve insulin sensitivity, and neprilysin inhibition may also influence glucose handling, so insulin requirements can fall. This may increase the risk of hypoglycemia, particularly at the start of therapy.
How serious is the interaction between Insulin aspart and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more closely when starting or changing sacubitril-valsartan. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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