Drug interactions
Insulin aspart + Selegiline
Severity: Moderate
Insulin aspart and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may enhance the glucose-lowering effect of insulin, increasing the risk of hypoglycemia. The effect is best described for nonselective agents and is less certain with selegiline.
What this interaction means in plain words
Insulin aspart and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart belongs to Endocrine; Selegiline belongs to Central Nervous System.
Why it happens
The mechanism is not established; MAO inhibition may alter glucose metabolism or insulin sensitivity.
What to do
Monitor blood glucose more frequently when selegiline is started or adjusted. Reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Insulin aspart
Frequently asked questions
Can I take Insulin aspart with Selegiline?
MediHelp rates the interaction as moderate. Insulin aspart and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors may enhance the glucose-lowering effect of insulin, increasing the risk of hypoglycemia. The effect is best described for nonselective agents and is less certain with selegiline.
How serious is the interaction between Insulin aspart and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when selegiline is started or adjusted. Reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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