Drug interactions
Insulin aspart + Somapacitan
Severity: Moderate
Insulin aspart and Somapacitan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone reduces insulin sensitivity and can raise blood glucose. Patients on insulin may therefore need higher doses after growth hormone is started.
What this interaction means in plain words
Insulin aspart and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart belongs to Endocrine; Somapacitan belongs to Endocrine.
Why it happens
Growth hormone causes insulin resistance by promoting lipolysis and reducing peripheral glucose uptake, opposing insulin action.
What to do
Monitor blood glucose after starting or changing the somapacitan dose and titrate insulin aspart as needed. Adjust insulin down again if growth hormone is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart
Other interactions of Somapacitan
- Alogliptin-metformin + Somapacitan Moderate
- Alogliptin-pioglitazone + Somapacitan Moderate
- Alogliptin + Somapacitan Moderate
- Bazedoxifene-conjugated estrogens + Somapacitan Moderate
- Canagliflozin-metformin + Somapacitan Moderate
- Chlorpropamide + Somapacitan Moderate
Frequently asked questions
Can I take Insulin aspart with Somapacitan?
MediHelp rates the interaction as moderate. Insulin aspart and Somapacitan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone reduces insulin sensitivity and can raise blood glucose. Patients on insulin may therefore need higher doses after growth hormone is started.
How serious is the interaction between Insulin aspart and Somapacitan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or changing the somapacitan dose and titrate insulin aspart as needed. Adjust insulin down again if growth hormone is stopped.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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