Drug interactions
Insulin aspart-insulin aspart protamine + Nateglinide
Severity: Moderate
Insulin aspart-insulin aspart protamine and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nateglinide stimulates insulin release and, combined with exogenous insulin, increases the risk of hypoglycemia. This combination is not generally recommended in practice.
What this interaction means in plain words
Insulin aspart-insulin aspart protamine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart-insulin aspart protamine belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect: nateglinide closes pancreatic beta-cell K-ATP channels to increase endogenous insulin secretion on top of administered insulin.
What to do
Monitor blood glucose closely and reduce the insulin dose if hypoglycemia occurs. Reassess whether both agents are needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Insulin aspart-insulin aspart protamine with Nateglinide?
MediHelp rates the interaction as moderate. Insulin aspart-insulin aspart protamine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nateglinide stimulates insulin release and, combined with exogenous insulin, increases the risk of hypoglycemia. This combination is not generally recommended in practice.
How serious is the interaction between Insulin aspart-insulin aspart protamine and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the insulin dose if hypoglycemia occurs. Reassess whether both agents are needed.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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