Drug interactions
Insulin aspart-insulin aspart protamine + Niacin
Severity: Moderate
Insulin aspart-insulin aspart protamine and Niacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Niacin at lipid-lowering doses can worsen insulin resistance and raise blood glucose, reducing the effectiveness of insulin. Higher insulin doses may be needed.
What this interaction means in plain words
Insulin aspart-insulin aspart protamine and Niacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Insulin aspart-insulin aspart protamine belongs to Endocrine; Niacin belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism: niacin impairs insulin sensitivity and increases hepatic glucose production.
What to do
Monitor blood glucose after starting or raising niacin and increase insulin as needed. Reduce insulin again if niacin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Other interactions of Niacin
- Alogliptin-metformin + Niacin Moderate
- Atorvastatin + Niacin Moderate
- Canagliflozin-metformin + Niacin Moderate
- Cholestyramine + Niacin Moderate
- Colestipol + Niacin Moderate
- Dapagliflozin-metformin + Niacin Moderate
Frequently asked questions
Can I take Insulin aspart-insulin aspart protamine with Niacin?
MediHelp rates the interaction as moderate. Insulin aspart-insulin aspart protamine and Niacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Niacin at lipid-lowering doses can worsen insulin resistance and raise blood glucose, reducing the effectiveness of insulin. Higher insulin doses may be needed.
How serious is the interaction between Insulin aspart-insulin aspart protamine and Niacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or raising niacin and increase insulin as needed. Reduce insulin again if niacin is stopped.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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